【INTENDED USE】
【SUMMARY】
Tetanus is a fatal disease caused by anaerobic Gram-positive bacterium named Clostridium tetani, which can produce tetanus exotoxin that can block inhibitory synapses on motor neurons in the central nervous system (CNS) . At present, the most effective strat- egy against tetanus disease is vaccination of human tetanus antibody immunoglobulin or tetanus toxoid. The level of tetanus antibody after vaccination in human body indicates the individual immunity, and people with lower-than-minimum protected level (0.01 IU/mL) has lethal risk to be infected with tetanus, particularly in the case of injury. According to WHO, the level of effective protective tetanus antibody is 0.1IU/ml. Detection of anti-tetanus antibody levels is necessary for both determination of the immune status of individuals and also for planning preventive measures .