Human monkeypox (HMPX), caused by the monkeypox virus (MPXV) which is a doublestranded DNA virus, a member of the orthopoxvirus genus within the Poxviridae family. It is a viral zoonotic disease, meaning that it can spread from animals to humans. It can also spread between people.The incubation period of monkeypox can range from 5 to 21 days. The febrile stage of illness usually lasts 1 to 3 days with symptoms including fever, intense headache, lymphadenopathy (swelling of the lymph nodes), back pain, myalgia (muscle ache), and an intense asthenia (lack of energy). The febrile stage is followed by the skin eruption stage, lasting for 2 to 4 weeks. Lesions evolve from macules (lesions with a flat base) to papules (raised firm painful lesions) to vesicles (filled with clear fluid) to pustules (filled with pus), followed by scabs or crusts. .The Human Monkeypox Virus Antigen Rapid Test Cassette(Lesion exudate/Oropharyngeal)is a rapid test that utilizes a combination of Monkeypox Virus antigen coated colored particles for the detection Monkeypox Virus antigen in lesion exudate/ oropharyngeal swab.