Tetanus is a fatal disease caused by anaerobic Gram-positive bacterium named Clostridium tetani, which can produce tetanus exotoxin that can block inhibitory synapses on motor neurons in the central nervous system (CNS) . At present, the most effective strat- egy against tetanus disease is vaccination of human tetanus antibody immunoglobulin or tetanus toxoid. The level of tetanus antibody after vaccination in human body indicates the individual immunity, and people with lower-than-minimum protected level (0.01 IU/mL) has lethal risk to be infected with tetanus, particularly in the case of injury. According to WHO, the level of effective protective tetanus antibody is 0.1IU/ml. Detection of anti-tetanus antibody levels is necessary for both determination of the immune status of individuals and also for planning preventive measures.

 

How to diagnose tetanus rapidly and accurately has always been a big challenge for clinicians specialized in the field of medicine. Recently, Hysen Biotech Inc. has announced the launch of a new tetanus rapid test method - Hysen Tetanus Antibody Rapid Test. This method can detect tetanus toxins within minutes, significantly shortening the time required for traditional laboratory diagnosis.

The Hysen Tetanus Antibody Rapid Test Cassette (Whole blood/Serum/Plasma) is a qualitative membrane based immunoassay for the detection of antibodies to tetanus toxin in human whole blood, serum, or plasma. In this test procedure, Anti-human IgG is coated in test line region. During testing, the specimen reacts with tetanus toxin antigen coated particles in the test cassette. The mixture then migrates upward on the membrane chromatographically by capillary action and reacts with the anti-human IgG in test line region. If the specimen contains antibodies to tetanus toxin, a colored line will appear in test line region. Therefore, if the specimen contains antibodies to tetanus toxin, a colored line will appear in test line region. If the specimen does not contain antibodies to tetanus toxin, no colored line will appear in the test line regions, indicating a negative result. To serve as a procedural control, a colored line will always appear in the control line region, indicating that the proper volume of specimen has been added and membrane wicking has occurred

 

The clinical validation of Hysen Tetanus Antibody Rapid Test shows impressive results. In a recent study involving over 300 patients, Hysen Tetanus Antibody Rapid Test got Relative Sensitivity: 100%; Relative Specificity: 96.3%;Accuracy:96.9% compared with ELIZA kits.

 

The introduction of Hysen Tetanus Antibody Rapid Test has significant implications for the innovation of global health. Tetanus remains a critical public health issue in many low- and middle-income countries, where accessibility to prompt and accurate diagnosis is limited. The availability of this rapid test not only improves patient outcomes but also reduces the burden on healthcare systems by streamlining the diagnostic process.

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Post time:2024-02-06